Thursday 31 December 2009

Mirtazapin Hexal




Mirtazapin Hexal may be available in the countries listed below.


Ingredient matches for Mirtazapin Hexal



Mirtazapine

Mirtazapine is reported as an ingredient of Mirtazapin Hexal in the following countries:


  • Austria

  • Denmark

  • Finland

  • Germany

  • Luxembourg

  • Sweden

International Drug Name Search

Thursday 24 December 2009

Neurexal




Neurexal may be available in the countries listed below.


Ingredient matches for Neurexal



Gabapentin

Gabapentin is reported as an ingredient of Neurexal in the following countries:


  • South Africa

International Drug Name Search

Thursday 17 December 2009

Rexicam




Rexicam may be available in the countries listed below.


Ingredient matches for Rexicam



Piroxicam

Piroxicam is reported as an ingredient of Rexicam in the following countries:


  • Indonesia

International Drug Name Search

Vermitan




Vermitan may be available in the countries listed below.


In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Vermitan



Albendazole

Albendazole is reported as an ingredient of Vermitan in the following countries:


  • Germany

International Drug Name Search

Tuesday 15 December 2009

Sandoz Bromazepam




Sandoz Bromazepam may be available in the countries listed below.


Ingredient matches for Sandoz Bromazepam



Bromazepam

Bromazepam is reported as an ingredient of Sandoz Bromazepam in the following countries:


  • South Africa

International Drug Name Search

Monday 14 December 2009

Granisetoron




Granisetoron may be available in the countries listed below.


Ingredient matches for Granisetoron



Granisetron

Granisetron is reported as an ingredient of Granisetoron in the following countries:


  • Japan

International Drug Name Search

Sunday 13 December 2009

Methixart




Methixart may be available in the countries listed below.


Ingredient matches for Methixart



Metixene

Metixene hydrochloride (a derivative of Metixene) is reported as an ingredient of Methixart in the following countries:


  • Japan

International Drug Name Search

Saturday 12 December 2009

Céfaline Hauth




Céfaline Hauth may be available in the countries listed below.


Ingredient matches for Céfaline Hauth



Caffeine

Caffeine is reported as an ingredient of Céfaline Hauth in the following countries:


  • France

Paracetamol

Paracetamol is reported as an ingredient of Céfaline Hauth in the following countries:


  • France

International Drug Name Search

Anétholtrithione




Anétholtrithione may be available in the countries listed below.


Ingredient matches for Anétholtrithione



Anetholtrithion

Anétholtrithione (DCF) is also known as Anetholtrithion (JAN)

International Drug Name Search

Glossary

DCFDénomination Commune Française
JANJapanese Accepted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Tuesday 8 December 2009

Ophtalin




Ophtalin may be available in the countries listed below.


Ingredient matches for Ophtalin



Hyaluronic Acid

Hyaluronic Acid sodium salt (a derivative of Hyaluronic Acid) is reported as an ingredient of Ophtalin in the following countries:


  • Tunisia

International Drug Name Search

Thursday 3 December 2009

Mydriaticum




Mydriaticum may be available in the countries listed below.


Ingredient matches for Mydriaticum



Tropicamide

Tropicamide is reported as an ingredient of Mydriaticum in the following countries:


  • Austria

  • Bangladesh

  • France

  • Luxembourg

International Drug Name Search

Tuesday 24 November 2009

Methionin Domesco




Methionin Domesco may be available in the countries listed below.


Ingredient matches for Methionin Domesco



Methionine

Methionine is reported as an ingredient of Methionin Domesco in the following countries:


  • Vietnam

International Drug Name Search

Sunday 22 November 2009

Recognan S




Recognan S may be available in the countries listed below.


Ingredient matches for Recognan S



Citicoline

Citicoline is reported as an ingredient of Recognan S in the following countries:


  • Japan

International Drug Name Search

Friday 20 November 2009

Metformin Bluefish




Metformin Bluefish may be available in the countries listed below.


Ingredient matches for Metformin Bluefish



Metformin

Metformin hydrochloride (a derivative of Metformin) is reported as an ingredient of Metformin Bluefish in the following countries:


  • Germany

  • Sweden

International Drug Name Search

Desferal




In some countries, this medicine may only be approved for veterinary use.


In the US, Desferal (deferoxamine systemic) is a member of the following drug classes: antidotes, chelating agents and is used to treat Iron Poisoning - Acute and Iron Poisoning - Chronic.

US matches:

  • Desferal

UK matches:

  • Desferal Vials, 500mg or 2g (SPC)

Ingredient matches for Desferal



Deferoxamine

Deferoxamine is reported as an ingredient of Desferal in the following countries:


  • Ghana

  • Guyana

  • India

  • Kenya

  • Libya

  • Nigeria

  • Russian Federation

  • Sudan

  • Tanzania

  • Turkey

  • Zimbabwe

Deferoxamine hydrochloride (a derivative of Deferoxamine) is reported as an ingredient of Desferal in the following countries:


  • Czech Republic

Deferoxamine mesilate (a derivative of Deferoxamine) is reported as an ingredient of Desferal in the following countries:


  • Argentina

  • Australia

  • Austria

  • Bahrain

  • Belgium

  • Brazil

  • Bulgaria

  • Canada

  • Chile

  • China

  • Colombia

  • Denmark

  • Finland

  • Germany

  • Greece

  • Hong Kong

  • Hungary

  • Indonesia

  • Ireland

  • Israel

  • Italy

  • Japan

  • Luxembourg

  • Malaysia

  • Malta

  • Netherlands

  • Norway

  • Oman

  • Philippines

  • Poland

  • Portugal

  • Romania

  • Slovakia

  • South Africa

  • Sri Lanka

  • Sweden

  • Switzerland

  • Taiwan

  • Thailand

  • United Kingdom

  • United States

  • Vietnam

International Drug Name Search

Glossary

SPC Summary of Product Characteristics (UK)

Click for further information on drug naming conventions and International Nonproprietary Names.

Sunday 15 November 2009

Quilox




Quilox may be available in the countries listed below.


Ingredient matches for Quilox



Ciprofloxacin

Ciprofloxacin is reported as an ingredient of Quilox in the following countries:


  • Philippines

International Drug Name Search

Wednesday 11 November 2009

Lyosan




Lyosan may be available in the countries listed below.


Ingredient matches for Lyosan



Losartan

Losartan potassium salt (a derivative of Losartan) is reported as an ingredient of Lyosan in the following countries:


  • Greece

International Drug Name Search

Saturday 31 October 2009

Metoclopramida Kern Pharma




Metoclopramida Kern Pharma may be available in the countries listed below.


Ingredient matches for Metoclopramida Kern Pharma



Metoclopramide

Metoclopramide hydrochloride (a derivative of Metoclopramide) is reported as an ingredient of Metoclopramida Kern Pharma in the following countries:


  • Spain

International Drug Name Search

Sunday 25 October 2009

Triherpine




Triherpine may be available in the countries listed below.


Ingredient matches for Triherpine



Trifluridine

Trifluridine is reported as an ingredient of Triherpine in the following countries:


  • Italy

International Drug Name Search

Thursday 22 October 2009

Medkiron




Medkiron may be available in the countries listed below.


Ingredient matches for Medkiron



Medroxyprogesterone

Medroxyprogesterone 17α-acetate (a derivative of Medroxyprogesterone) is reported as an ingredient of Medkiron in the following countries:


  • Japan

International Drug Name Search

Tuesday 20 October 2009

Mannitol Demo




Mannitol Demo may be available in the countries listed below.


Ingredient matches for Mannitol Demo



Mannitol

Mannitol is reported as an ingredient of Mannitol Demo in the following countries:


  • Greece

International Drug Name Search

Friday 16 October 2009

AF-TIPA




AF-TIPA may be available in the countries listed below.


Ingredient matches for AF-TIPA



Oxymetazoline

Oxymetazoline is reported as an ingredient of AF-TIPA in the following countries:


  • Israel

International Drug Name Search

Thursday 15 October 2009

Aclarubicine




Aclarubicine may be available in the countries listed below.


Ingredient matches for Aclarubicine



Aclarubicin

Aclarubicine (DCF) is also known as Aclarubicin (Rec.INN)

International Drug Name Search

Glossary

DCFDénomination Commune Française
Rec.INNRecommended International Nonproprietary Name (World Health Organization)

Click for further information on drug naming conventions and International Nonproprietary Names.

Monday 12 October 2009

Nuta




Nuta may be available in the countries listed below.


In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Nuta



Sodium Selenite

Sodium Selenite is reported as an ingredient of Nuta in the following countries:


  • France

Tocopherol, α-

Tocopherol, α- acetate (a derivative of Tocopherol, α-) is reported as an ingredient of Nuta in the following countries:


  • France

International Drug Name Search

Sunday 11 October 2009

Xaclot




Xaclot may be available in the countries listed below.


Ingredient matches for Xaclot



Ozagrel

Ozagrel sodium (a derivative of Ozagrel) is reported as an ingredient of Xaclot in the following countries:


  • Japan

International Drug Name Search

Wednesday 7 October 2009

Tobral




Tobral may be available in the countries listed below.


Ingredient matches for Tobral



Tobramycin

Tobramycin is reported as an ingredient of Tobral in the following countries:


  • Italy

International Drug Name Search

Tuesday 6 October 2009

Cemado




Cemado may be available in the countries listed below.


Ingredient matches for Cemado



Cefamandole

Cefamandole nafate (a derivative of Cefamandole) is reported as an ingredient of Cemado in the following countries:


  • Italy

International Drug Name Search

Sunday 4 October 2009

Morphine Hydrochloride




Morphine Hydrochloride may be available in the countries listed below.


Ingredient matches for Morphine Hydrochloride



Morphine

Morphine Hydrochloride (BANM) is known as Morphine in the US.

International Drug Name Search

Glossary

BANMBritish Approved Name (Modified)

Click for further information on drug naming conventions and International Nonproprietary Names.

Friday 2 October 2009

Methaddict




Methaddict may be available in the countries listed below.


Ingredient matches for Methaddict



Methadone

Methadone hydrochloride (a derivative of Methadone) is reported as an ingredient of Methaddict in the following countries:


  • Luxembourg

International Drug Name Search

Saturday 26 September 2009

Flutenal Sali




Flutenal Sali may be available in the countries listed below.


Ingredient matches for Flutenal Sali



Flupamesone

Flupamesone is reported as an ingredient of Flutenal Sali in the following countries:


  • Spain

Salicylic Acid

Salicylic Acid is reported as an ingredient of Flutenal Sali in the following countries:


  • Spain

International Drug Name Search

Thursday 24 September 2009

Mariotton




Mariotton may be available in the countries listed below.


Ingredient matches for Mariotton



Norfloxacin

Norfloxacin is reported as an ingredient of Mariotton in the following countries:


  • Japan

International Drug Name Search

Wednesday 23 September 2009

Methylfenidaat ratiopharm




Methylfenidaat ratiopharm may be available in the countries listed below.


Ingredient matches for Methylfenidaat ratiopharm



Methylphenidate

Methylphenidate hydrochloride (a derivative of Methylphenidate) is reported as an ingredient of Methylfenidaat ratiopharm in the following countries:


  • Netherlands

International Drug Name Search

Thursday 17 September 2009

Sertraline Teva




Sertraline Teva may be available in the countries listed below.


Ingredient matches for Sertraline Teva



Sertraline

Sertraline is reported as an ingredient of Sertraline Teva in the following countries:


  • Israel

Sertraline hydrochloride (a derivative of Sertraline) is reported as an ingredient of Sertraline Teva in the following countries:


  • Estonia

  • France

  • Latvia

  • Lithuania

International Drug Name Search

Thursday 10 September 2009

Pinimenthol




Pinimenthol may be available in the countries listed below.


Ingredient matches for Pinimenthol



Levomenthol

Levomenthol is reported as an ingredient of Pinimenthol in the following countries:


  • Switzerland

International Drug Name Search

Wednesday 9 September 2009

Prephen




Prephen may be available in the countries listed below.


Ingredient matches for Prephen



Phenol

Phenol is reported as an ingredient of Prephen in the following countries:


  • New Zealand

International Drug Name Search

Tuesday 8 September 2009

Paxium




Paxium may be available in the countries listed below.


Ingredient matches for Paxium



Chlordiazepoxide

Chlordiazepoxide is reported as an ingredient of Paxium in the following countries:


  • Portugal

International Drug Name Search

Sunday 23 August 2009

Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment


Pronunciation: BAS-i-TRAY-sin/HYE-droe-KOR-ti-sone/NEE-oh-MYE-sin/POL-ee-MIX-in
Generic Name: Bacitracin/Hydrocortisone/Neomycin/Polymyxin
Brand Name: Cortisporin


Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment is used for:

Treating steroid-sensitive skin disorders that have a secondary infection caused by bacteria.


Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment is a combination of 3 antibiotics and a corticosteroid. The antibiotics kill the bacteria and hydrocortisone reduces inflammation.


Do NOT use Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment if:


  • you are allergic to any ingredient in Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment

  • you have a fungal (eg, ringworm), viral (eg, herpes simplex, chickenpox), or tuberculosis (TB) infection of the skin

Contact your doctor or health care provider right away if any of these apply to you.



Before using Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment:


Some medical conditions may interact with Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have recently received or will be receiving a vaccine, or you have had a positive TB skin test

  • if you have thinning of the skin

Some MEDICINES MAY INTERACT with Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment. Because little, if any, of Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment is absorbed into the blood, the risk of it interacting with another medicine is low.


Ask your health care provider if Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment:


Use Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment is for external use only. Avoid contact with the eyes.

  • Before using Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment, clean the affected area. Apply a small amount of Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment (an amount equal to the surface of the tip of a finger) on the area as directed. The treated area may be covered with a clean bandage.

  • To clear up your infection completely, use Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment for the full course of treatment. Keep using it even if you feel better in a few days.

  • If you miss a dose of Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment.



Important safety information:


  • Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment only works against bacteria; it does not treat viral infections (eg, the common cold).

  • Be sure to use Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

  • If your symptoms do not get better within 7 days or if they get worse, check with your doctor.

  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

  • Long-term or repeated use of Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

  • Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

  • Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment while you are pregnant. It is not known if Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment is found in breast milk. If you are or will be breast-feeding while you are using Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment, check with your doctor or pharmacist to discuss the risks to your baby.


Possible side effects of Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Burning, dryness, or itching of skin; worsening of condition.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); hearing or kidney problems; second infection.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.



If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.


Proper storage of Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment:

Store Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Keep Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment out of the reach of children and away from pets.


General information:


  • If you have any questions about Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment, please talk with your doctor, pharmacist, or other health care provider.

  • Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Bacitracin/Hydrocortisone/Neomycin/Polymyxin Ointment. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Bacitracin/Hydrocortisone/Neomycin/Polymyxin resources


  • Bacitracin/Hydrocortisone/Neomycin/Polymyxin Use in Pregnancy & Breastfeeding
  • Bacitracin/Hydrocortisone/Neomycin/Polymyxin Drug Interactions
  • Bacitracin/Hydrocortisone/Neomycin/Polymyxin Support Group
  • 0 Reviews for Bacitracin/Hydrocortisone/Neomycin/Polymyxin - Add your own review/rating


Compare Bacitracin/Hydrocortisone/Neomycin/Polymyxin with other medications


  • Bacterial Skin Infection
  • Dermatitis

Metronidazolas L




Metronidazolas L may be available in the countries listed below.


Ingredient matches for Metronidazolas L



Metronidazole

Metronidazole is reported as an ingredient of Metronidazolas L in the following countries:


  • Lithuania

International Drug Name Search

Friday 21 August 2009

Bicaprol




Bicaprol may be available in the countries listed below.


Ingredient matches for Bicaprol



Bicalutamide

Bicalutamide is reported as an ingredient of Bicaprol in the following countries:


  • Greece

International Drug Name Search

Sunday 16 August 2009

Karicare Barrier Cream




Karicare Barrier Cream may be available in the countries listed below.


Ingredient matches for Karicare Barrier Cream



Cetrimide

Cetrimide is reported as an ingredient of Karicare Barrier Cream in the following countries:


  • New Zealand

Dimeticone

Dimeticone is reported as an ingredient of Karicare Barrier Cream in the following countries:


  • New Zealand

International Drug Name Search

Saturday 15 August 2009

Aceralgin




Aceralgin may be available in the countries listed below.


Ingredient matches for Aceralgin



Dextropropoxyphene

Dextropropoxyphene hydrochloride (a derivative of Dextropropoxyphene) is reported as an ingredient of Aceralgin in the following countries:


  • Vietnam

Paracetamol

Paracetamol is reported as an ingredient of Aceralgin in the following countries:


  • Vietnam

International Drug Name Search

Friday 14 August 2009

Candacide




Candacide may be available in the countries listed below.


Ingredient matches for Candacide



Nystatin

Nystatin is reported as an ingredient of Candacide in the following countries:


  • South Africa

International Drug Name Search

Diacerein Proel




Diacerein Proel may be available in the countries listed below.


Ingredient matches for Diacerein Proel



Diacerein

Diacerein is reported as an ingredient of Diacerein Proel in the following countries:


  • Greece

International Drug Name Search

Wednesday 12 August 2009

Marfarin




Marfarin may be available in the countries listed below.


Ingredient matches for Marfarin



Warfarin

Warfarin clathrate sodium salt (a derivative of Warfarin) is reported as an ingredient of Marfarin in the following countries:


  • Hungary

International Drug Name Search

Sunday 9 August 2009

Cefotaxima Fabra




Cefotaxima Fabra may be available in the countries listed below.


Ingredient matches for Cefotaxima Fabra



Cefotaxime

Cefotaxime sodium salt (a derivative of Cefotaxime) is reported as an ingredient of Cefotaxima Fabra in the following countries:


  • Argentina

International Drug Name Search

Tuesday 28 July 2009

Medicort




In the US, Medicort is a member of the drug class glucocorticoids and is used to treat Asthma - acute, Bullous Pemphigoid, Dermatitis, Immunosuppression, Inflammatory Conditions, Multiple Sclerosis, Nephrotic Syndrome, Pemphigoid and Pemphigus.

Ingredient matches for Medicort



Dexamethasone

Dexamethasone is reported as an ingredient of Medicort in the following countries:


  • Peru

Dexamethasone 21-(disodium phosphate) (a derivative of Dexamethasone) is reported as an ingredient of Medicort in the following countries:


  • Peru

Fluticasone

Fluticasone propionate (a derivative of Fluticasone) is reported as an ingredient of Medicort in the following countries:


  • Indonesia

International Drug Name Search

Wednesday 22 July 2009

Clotrimazol Bayhealth




Clotrimazol Bayhealth may be available in the countries listed below.


Ingredient matches for Clotrimazol Bayhealth



Clotrimazole

Clotrimazole is reported as an ingredient of Clotrimazol Bayhealth in the following countries:


  • Spain

International Drug Name Search

Thursday 16 July 2009

Cefaxetil




Cefaxetil may be available in the countries listed below.


Ingredient matches for Cefaxetil



Cefuroxime

Cefuroxime axetil (a derivative of Cefuroxime) is reported as an ingredient of Cefaxetil in the following countries:


  • Germany

International Drug Name Search

Rontilona




Rontilona may be available in the countries listed below.


Ingredient matches for Rontilona



Fluticasone

Fluticasone propionate (a derivative of Fluticasone) is reported as an ingredient of Rontilona in the following countries:


  • Portugal

International Drug Name Search

Wednesday 15 July 2009

Isozid-H




Isozid-H may be available in the countries listed below.


Ingredient matches for Isozid-H



Hexetidine

Hexetidine is reported as an ingredient of Isozid-H in the following countries:


  • Austria

International Drug Name Search

Monday 13 July 2009

Demadex


Generic Name: Torsemide
Class: Loop Diuretics
VA Class: CV702
Chemical Name: N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl) amino]-3-pyridinesulfonamide
Molecular Formula: C16H20N4O3S
CAS Number: 56211-40-6

Introduction

A sulfonamide, loop-type diuretic and antihypertensive agent.1 a


Uses for Demadex


Edema


Management of edema associated with CHF1 4 or hepatic1 or renal1 disease (including chronic renal failure).a


Hypertension


Management of hypertension (alone or in combination with other classes of antihypertensive agents).1 2 3


One of several preferred initial therapies in hypertensive patients with CHF, acute pulmonary edema, or renal disease.2 3


Can be used as monotherapy for initial management of uncomplicated hypertension;1 2 3 a however, thiazide diuretics are preferred by JNC 7.11


Demadex Dosage and Administration


General



  • The manufacturer states that since oral and IV doses of torsemide are therapeutically equivalent, torsemide dosage is identical for oral or IV administration.1



Edema



  • Most experts state that all patients with symptomatic CHF who have evidence for, or a prior history of, fluid retention generally should receive diuretic therapy in conjunction with moderate sodium restriction (≤3 g of sodium daily), an ACE inhibitor, and usually a β-blocker, with or without a cardiac glycoside.4




  • Hospitalization of the patient during initiation of therapy is advisable for patients with hepatic cirrhosis and ascites or chronic renal failure.1 a b




  • Chronic use of any diuretic in hepatic disease has not been adequately studied.1 a



Administration


Administer orally, by direct IV injection, or by continuous IV infusion.1


Oral Administration


Administer orally without regard to meals.1


IV Administration


For solution and drug compatibility information, see Compatibility under Stability.


IV administration may be used when a rapid onset of diuresis is desired or when oral therapy is not practical.1


If torsemide is administered through an IV line, flush the IV line with 0.9% sodium chloride before and after administration.a


Dilution

For IV infusion, dilute in 5% dextrose, 0.9% sodium chloride, or 0.45% sodium chloride injection.a


Rate of Administration

For direct IV injection, administer slowly over a period of 2 minutes.1


Dosage


Adults


Edema

CHF

Oral

Initially, 10–20 mg, given as a single dose.1 Increase as necessary by approximately doubling daily dosage until desired diuresis is attained.1 Single doses exceeding 200 mg not adequately studied.1


IV

Initially, 10–20 mg, given as a single dose.1 Increase as necessary by approximately doubling dosage until desired diuresis is attained.1 Single doses exceeding 200 mg not adequately studied.1


Hypertension

Oral

Initially, 5 mg once daily.1 If adequate hypotensive response not attained in 4–6 weeks, may increase dosage to 10 mg once daily.1 If adequate response not observed with 10 mg once daily, an additional antihypertensive agent should be added to antihypertensive therapy.1


IV

Initially, 5 mg once daily.1 If adequate hypotensive response not attained in 4–6 weeks, may increase dosage to 10 mg once daily.1 If adequate response not observed with 10 mg once daily, an additional antihypertensive agent should be added to antihypertensive therapy.1


Prescribing Limits


Adults


Edema

CHF

Oral

Maximum of 200 mg as a single dose (daily).1


IV

Maximum of 200 mg as a single dose (daily).1


Hypertension

Oral

Maximum of 10 mg once daily.1


IV

Maximum of 10 mg once daily.1


Special Populations


Renal Impairment


Edema

Edema Associated with Chronic Renal Failure

Oral or IV

In adults, initially, 20 mg once daily.1 Increase as necessary by approximately doubling dosage until desired diuresis is attained.1 Single doses exceeding 200 mg not adequately studied.1 a


Hepatic Impairment


Chronic use in hepatic disease not adequately studied.1


Edema

Edema Associated with Hepatic Cirrhosis

Oral or IV

In adults, initially, 5–10 mg once daily, given concomitantly with an aldosterone antagonist or a potassium-sparing diuretic.a Increase as necessary by approximately doubling dosage until desired diuresis is attained.a Single doses exceeding 40 mg not adequately studied.1


Cautions for Demadex


Contraindications



  • Anuria.1




  • Known hypersensitivity to torsemide or to sulfonylureas.1



Warnings/Precautions


Warnings


Hepatic Effects

Sudden alterations of electrolyte balance in patients with cirrhosis may precipitate hepatic coma; use with caution in patients with hepatic cirrhosis and ascites.1


Therapy in such patients is best initiated in the hospital.1 Use an aldosterone antagonist or potassium-sparing agent concomitantly with torsemide to prevent hypokalemia and metabolic alkalosis in such patients.1


Ototoxicity

Tinnitus and hearing loss, usually reversible, have been observed following rapid IV injection of other loop diuretics and following oral torsemide administration.1 Administer IV slowly (over 2 minutes); do not exceed 200 mg as a single dose.1


Fluid, Electrolyte, and Cardiovascular Effects

Observe carefully for manifestations of fluid and electrolyte depletion (e.g., dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, nausea, vomiting).1 a


Excessive diuresis may cause dehydration and blood volume reduction with circulatory collapse and possibly vascular thrombosis and embolism, particularly in geriatric patients.1 a


Laboratory changes may include altered serum concentrations of sodium, chloride, and potassium; acid-base abnormalities; and increased BUN.1 a If electrolyte imbalance, hypovolemia, or prerenal azotemia develops, torsemide should be discontinued until the abnormality is corrected; treatment then may be restarted at a reduced dosage.1 a


Risk of hypokalemia, especially with brisk diuresis, with inadequate oral electrolyte intake, in those with cirrhosis, or during concomitant use of corticosteroids or ACTH.1 a Risk of arrhythmias secondary to hypokalemia in patients with cardiovascular disease, especially those receiving concomitant therapy with a cardiac glycoside.1 a


Periodically monitor serum potassium and other electrolyte concentrations.1 a


General Precautions


Endocrine Effects

Possible increased blood glucose concentrations; hyperglycemia occurred rarely. 1 a


Renal and Electrolyte Effects

Small, dose-related, reversible increases in BUN, serum creatinine, and uric acid concentrations reported.1 a Symptomatic gout reported at an incidence similar to placebo.1


Slight alterations in calcium and magnesium concentrations.1 a


Other Effects

Increases in total plasma cholesterol concentrations may occur; usually subside during chronic therapy.1 a


Increases in plasma triglyceride concentrations reported.1 a


In long-term studies, no clinically important differences in lipid profiles compared to baseline.1 a


No clinically important effects on hemoglobin; hematocrit; WBC, erythrocyte, or platelet counts; or serum alkaline phosphatase concentrations.1 a


Specific Populations


Pregnancy

Category B.1


Lactation

Not known whether torsemide is distributed into milk.1 Caution if used in nursing women.1


Pediatric Use

Safety and efficacy not established.1


Renal calcifications reported in severely premature infants with edema secondary to patent ductus arteriosus and hyaline membrane disease receiving another loop diuretic.1 a Increased risk of persistent patent ductus arteriosus in premature neonates with hyaline membrane disease receiving another loop diuretic also has been reported.1 a


Geriatric Use

No substantial differences in safety and efficacy relative to younger adults.1 a


Renal Impairment

Seizures reported in patients with acute renal failure receiving higher than recommended dosages of torsemide.1 a


Common Adverse Effects


Headache, excessive urination, dizziness, rhinitis, asthenia, diarrhea, ECG abnormality, increased cough.1 a


Interactions for Demadex


Specific Drugs



























Drug



Interaction



Comments



Cholestyramine



Decreased absorption of torsemide in animals1 a



Avoid simultaneous administration when used concomitantly1 a



Digoxin



Increased torsemide AUC1 a



Torsemide dosage adjustment not necessary1 a



Lithium



Reduced renal clearance of lithium and increased risk of lithium toxicity reported with other diuretics 1 a



Avoid concomitant use or use great caution1 a



Ototoxic drugs (e.g., aminoglycoside antibiotics, ethacrynic acid)



Possible additive ototoxic effect when ototoxic drugs used concomitantly with other diuretics, especially in those with impaired renal function1 a



Probenecid



Reduced secretion of torsemide into proximal tubule and decreased diuretic activity1 a



Salicylates (e.g., aspirin, NSAIAs)



Concomitant use of NSAIAs with another loop diuretic (furosemide) occasionally associated with renal dysfunction.1 a


Indomethacin may partially inhibit natriuretic effect of torsemide in those with dietary sodium restriction (50 mEq daily) 1 a


Concomitant use with high dosages of salicylates may result in salicylate toxicity1 a



Spironolactone



Reduced renal clearance of spironolactone1 a



Adjustment of spironolactone or torsemide dosage not necessary1 a


Demadex Pharmacokinetics


Absorption


Bioavailability


Bioavailability is approximately 80%.1


Onset


Following oral administration, onset of diuresis occurs within 1 hour; maximal effect during the first or second hour.1 a


Following IV administration, onset of diuresis occurs within 10 minutes; maximal effect within 1 hour.1 a


Duration


Diuretic effect persists 6–8 hours following oral or IV administration.1 a


Food


Food delays the time to peak plasma concentration following oral dosing but does not affect extent of absorption or diuretic activity.1 a


Plasma Concentrations


Following oral administration, peak plasma concentrations achieved within 1 hour.1


Distribution


Extent


Not known whether torsemide is distributed into milk.1 a


Plasma Protein Binding


>99%.1 a


Elimination


Metabolism


Hepatic metabolism accounts for approximately 80% of total clearance.1 a Carboxylic acid derivative, the major metabolite, is inactive.1 a


Elimination Route


Urinary excretion accounts for approximately 20% of total clearance in patients with normal renal function.1 a Most renal clearance occurs via active secretion of the drug by the proximal tubules into tubular urine.1 a


Half-life


Approximately 3.5 hours.1 a


Special Populations


In patients with decompensated CHF, hepatic and renal clearance are reduced, resulting in delivery of less drug to the intraluminal site of action and decreased natriuretic effect.1 a Total clearance is about half of that of healthy individuals; half-life and AUC increased.1 a


In patients with renal failure, renal clearance (but not total clearance) is reduced, resulting in delivery of less drug to the intraluminal site of action and decreased natriuretic effect.1 a


In patients with hepatic cirrhosis, renal clearance (but not total clearance) and half-life are increased.1


In geriatric patients, decreased renal clearance.1 a


Stability


Storage


Oral


Tablets

15–30°C.1 Do not freeze.1 a


Parenteral


Injection

15–30°C.1 a Do not freeze.1 a


Compatibility


For information on systemic interactions resulting from concomitant use, see Interactions.


Parenteral


Solution CompatibilityHID





Compatible



Dextrose 5% in water



Sodium chloride 0.45 or 0.9%





Y-Site CompatibilityHID

Compatible



Milrinone lactate


ActionsActions



  • Acts from within the lumen of the thick ascending portion of the loop of Henle, where it inhibits the sodium/potassium/chloride carrier system.1




  • Increases urinary excretion of sodium, chloride, and water without having an important effect on glomerular filtration rate, renal plasma flow, or acid-base balance.1



Advice to Patients



  • Risks associated with excessive fluid loss or electrolyte imbalance.1 a




  • Potential for postural hypotension; importance of rising slowly from a seated position.1




  • Importance of informing patients with diabetes mellitus that blood glucose concentrations may increase.1




  • Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses.1




  • Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1




  • Importance of informing patients of other important precautionary information.1 (See Cautions.)



Preparations


Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.


* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name





















































Torsemide

Routes



Dosage Forms



Strengths



Brand Names



Manufacturer



Oral



Tablets



5 mg*



Demadex (with povidone; scored)



Roche



Torsemide Tablets



Apotex, Par, Pliva, Roxane, Teva



10 mg*



Demadex (with povidone; scored)



Roche



Torsemide Tablets



Apotex, Par, Pliva, Roxane, Teva, UDL,



20 mg*



Demadex (with povidone; scored)



Roche



Torsemide Tablets



Apotex, Par, Pliva, Roxane, Teva, UDL



100 mg*



Demadex (with povidone; scored)



Roche



Torsemide Tablets



Apotex, Par, Pliva, Teva



Parenteral



Injection, for IV use



10 mg/mL



Demadex



Roche


Comparative Pricing


This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.


Demadex 10MG Tablets (MEDA PHARMACEUTICALS): 30/$43.69 or 90/$110.37


Demadex 100MG Tablets (MEDA PHARMACEUTICALS): 30/$160.99 or 90/$455.97


Demadex 20MG Tablets (MEDA PHARMACEUTICALS): 30/$55.99 or 90/$139.97


Torsemide 10MG Tablets (TEVA PHARMACEUTICALS USA): 30/$29.99 or 90/$79.97


Torsemide 100MG Tablets (TEVA PHARMACEUTICALS USA): 30/$89.99 or 90/$249.96


Torsemide 20MG Tablets (TEVA PHARMACEUTICALS USA): 30/$22.99 or 90/$59.98


Torsemide 5MG Tablets (CAMBER PHARMACEUTICALS): 30/$18.99 or 90/$56.97



Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.


The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions August 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.




References



1. Boehringer Mannheim. Demadex (torsemide) tablets and injection prescribing information. Rockville, MD: 1993 Oct.



2. National Heart, Lung, and Blood Institute National High Blood Pressure Education Program. The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC VI). Bethesda, MD: National Institutes of Health. (NIH publication No. 98-4080.)



3. Kaplan NM. Choice of initial therapy for hypertension. JAMA. 1996; 275:1577-80. [IDIS 365188] [PubMed 8622249]



4. Anon. Consensus recommendations for the management of chronic heart failure. On behalf of the membership of the advisory council to improve outcomes nationwide in heart failure. Part II. Management of heart failure: approaches to the prevention of heart failure. Am J Cardiol. 1999; 83:9-38A.



5. Izzo JL, Levy D, Black HR. Importance of systolic blood pressure in older Americans. Hypertension. 2000; 35:1021-4. [PubMed 10818056]



6. Frohlich ED. Recognition of systolic hypertension for hypertension. Hypertension. 2000; 35:1019-20. [PubMed 10818055]



7. Bakris GL, Williams M, Dworkin L et al. Preserving renal function in adults with hypertension and diabetes: a consensus approach. Am J Kidney Dis. 2000; 36:646-61. [IDIS 452007] [PubMed 10977801]



8. Associated Press (American Diabetes Association). Diabetics urged: drop blood pressure. Chicago, IL; 2000 Aug 29. Press Release from web site.



9. Appel LJ. The verdict from ALLHAT—thiazide diuretics are the preferred initial therapy for hypertension. JAMA. 2002; 288:3039-42. [IDIS 490723] [PubMed 12479770]



10. The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA. 2002; 288:2981-97. [IDIS 490721] [PubMed 12479763]



11. National Heart, Lung, and Blood Institute National High Blood Pressure Education Program. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) Express. Bethesda, MD: May 14 2003. From NIH website. (http://www.nhlbi.nih.gov/guidelines/hypertension/jncintro.htm). (Also published in JAMA. 2003; 289:2560-72.



a. Roche Pharmaceuticals. Demadex (torsemide) tablets and injection prescribing information. Nutley, NJ: 2003 Apr.



b. AHFS Drug Information 2007. McEvoy GK, ed. Furosemide. American Society of Health-System Pharmacists; 2007: 2690-4.



HID. Trissel LA. Handbook on injectable drugs. 14th ed. Bethesda, MD: American Society of Health-System Pharmacists; 2007:1581.



More Demadex resources


  • Demadex Side Effects (in more detail)
  • Demadex Use in Pregnancy & Breastfeeding
  • Drug Images
  • Demadex Drug Interactions
  • Demadex Support Group
  • 0 Reviews for Demadex - Add your own review/rating


  • Demadex Prescribing Information (FDA)

  • Demadex MedFacts Consumer Leaflet (Wolters Kluwer)

  • Demadex Concise Consumer Information (Cerner Multum)

  • Demadex Advanced Consumer (Micromedex) - Includes Dosage Information

  • Torsemide Prescribing Information (FDA)

  • Torsemide Professional Patient Advice (Wolters Kluwer)



Compare Demadex with other medications


  • Ascites
  • Edema
  • Heart Failure
  • High Blood Pressure
  • Nonobstructive Oliguria
  • Renal Failure

Thursday 9 July 2009

Prodilantin




Prodilantin may be available in the countries listed below.


Ingredient matches for Prodilantin



Fosphenytoin

Fosphenytoin disodium salt (a derivative of Fosphenytoin) is reported as an ingredient of Prodilantin in the following countries:


  • France

International Drug Name Search

Calcipotriene




Ingredient matches for Calcipotriene



Calcipotriol

Calcipotriene (USAN) is also known as Calcipotriol (Rec.INN)

International Drug Name Search

Glossary

Rec.INNRecommended International Nonproprietary Name (World Health Organization)
USANUnited States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Sudafed PE Nasal Decongestant




In the US, Sudafed PE Nasal Decongestant is a member of the following drug classes: decongestants, vasopressors and is used to treat Nasal Congestion.

Ingredient matches for Sudafed PE Nasal Decongestant



Phenylephrine

Phenylephrine hydrochloride (a derivative of Phenylephrine) is reported as an ingredient of Sudafed PE Nasal Decongestant in the following countries:


  • New Zealand

International Drug Name Search

Tuesday 7 July 2009

Zinmax Domesco




Zinmax Domesco may be available in the countries listed below.


Ingredient matches for Zinmax Domesco



Cefuroxime

Cefuroxime axetil (a derivative of Cefuroxime) is reported as an ingredient of Zinmax Domesco in the following countries:


  • Vietnam

International Drug Name Search

Monday 6 July 2009

Methazolamide




In the US, Methazolamide (methazolamide systemic) is a member of the drug class carbonic anhydrase inhibitors and is used to treat Glaucoma.

US matches:

  • Methazolamide

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

S01EC05

CAS registry number (Chemical Abstracts Service)

0000554-57-4

Chemical Formula

C5-H8-N4-O3-S2

Molecular Weight

236

Therapeutic Categories

Carbonic anhydrase inhibitor

Glaucoma treatment

Ophthalmic agent

Chemical Name

Acetamide, N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]-

Foreign Names

  • Methazolamidum (Latin)
  • Methazolamid (German)
  • Méthazolamide (French)
  • Metazolamida (Spanish)

Generic Names

  • Methazolamide (OS: BAN, JAN)
  • Méthazolamide (OS: DCF)
  • Methazolamide (PH: USP 32)

Brand Names

  • Apo-Methazolamide
    Apotex, Canada


  • Methazolamide
    Mikart, United States; Sandoz, United States; Teva USA, United States


  • Methazolamide-Teva
    Teva, Israel

International Drug Name Search

Glossary

BANBritish Approved Name
DCFDénomination Commune Française
JANJapanese Accepted Name
OSOfficial Synonym
PHPharmacopoeia Name
Rec.INNRecommended International Nonproprietary Name (World Health Organization)

Click for further information on drug naming conventions and International Nonproprietary Names.

Mirtazapin Arrow




Mirtazapin Arrow may be available in the countries listed below.


Ingredient matches for Mirtazapin Arrow



Mirtazapine

Mirtazapine is reported as an ingredient of Mirtazapin Arrow in the following countries:


  • Sweden

International Drug Name Search

Friday 26 June 2009

Estradiol Implants




Estradiol Implants may be available in the countries listed below.


Ingredient matches for Estradiol Implants



Estradiol

Estradiol is reported as an ingredient of Estradiol Implants in the following countries:


  • Singapore

International Drug Name Search

Thursday 25 June 2009

Septadine




Septadine may be available in the countries listed below.


Ingredient matches for Septadine



Povidone Iodine

Povidone-Iodine is reported as an ingredient of Septadine in the following countries:


  • Indonesia

  • Israel

  • South Africa

International Drug Name Search

Saturday 20 June 2009

Sachet Diet CS




Sachet Diet CS may be available in the countries listed below.


In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Sachet Diet CS



Colistin Sulfate

Colistin sulfate (a derivative of Colistin) is reported as an ingredient of Sachet Diet CS in the following countries:


  • France

Sulfadimidine

Sulfadimidine is reported as an ingredient of Sachet Diet CS in the following countries:


  • France

International Drug Name Search

Thursday 11 June 2009

Meloprol




Meloprol may be available in the countries listed below.


Ingredient matches for Meloprol



Meloxicam

Meloxicam is reported as an ingredient of Meloprol in the following countries:


  • Greece

International Drug Name Search

Tuesday 9 June 2009

Ranicodan




Ranicodan may be available in the countries listed below.


Ingredient matches for Ranicodan



Ranitidine

Ranitidine hydrochloride (a derivative of Ranitidine) is reported as an ingredient of Ranicodan in the following countries:


  • Denmark

International Drug Name Search

Friday 5 June 2009

Onglyza



Generic Name: saxagliptin (SAX a GLIP tin)

Brand Names: Onglyza


What is saxagliptin?

Saxagliptin is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating.


Saxagliptin is for people with type 2 diabetes. Saxagliptin is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes.


Saxagliptin may also be used for purposes not listed in this medication guide.


What is the most important information I should know about saxagliptin?


Do not use this medication if you are allergic to saxagliptin or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Before you take saxagliptin, tell your doctor if you have kidney disease or if you are on dialysis.


You may take this medicine with or without food. Follow your doctor's instructions.


Saxagliptin is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly other medications. It is important to use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.


What should I discuss with my healthcare provider before taking saxagliptin?


Do not use this medication if you are allergic to saxagliptin, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

To make sure you can safely take saxagliptin, tell your doctor if you have kidney disease or if you are on dialysis.


FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether saxagliptin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Saxagliptin should not be given to a child younger than 18 years old without a doctor's advice.

How should I take saxagliptin?


Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.


Your doctor may occasionally change your dose to make sure you get the best results.


You may take this medicine with or without food. Follow your doctor's instructions.


Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change.


Your doctor may want you to stop taking saxagliptin for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.


Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.


Saxagliptin is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly other medications. It is important to use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.


Store at room temperature away from moisture and heat

What happens if I miss a dose?


Take the missed dose as soon as you remember (be sure to take the medicine with food if your doctor has instructed you to). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).

What should I avoid while taking saxagliptin?


Follow your doctor's instructions about any restrictions on food, beverages, or activity.


Saxagliptin side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

  • severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;




  • pain or burning when you urinate;




  • swelling in your hands, ankles, or feet; or




  • easy bruising or bleeding.



Less serious side effects may include:



  • runny or stuffy nose, sore throat, cough;




  • headache; or




  • stomach pain.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect saxagliptin?


Tell your doctor about all other medications you use, especially:



  • conivaptan (Vaprisol);




  • diclofenac (Arthrotec, Cataflam, Voltaren, Flector Patch, Solareze);




  • imatinib (Gleevec);




  • isoniazid (for treating tuberculosis);




  • an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), or telithromycin (Ketek);




  • an antidepressant such as nefazodone;




  • antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);




  • heart or blood pressure medication such as nicardipine (Cardene) or quinidine (Quin-G);




  • HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir, Kaletra); or




  • insulin or an oral diabetes medication such as glipizide (Glucotrol, Metaglip), glimepiride (Amaryl, Avandaryl, Duetact), glyburide (DiaBeta, Micronase, Glucovance), and others.



This list is not complete and other drugs may interact with saxagliptin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.



More Onglyza resources


  • Onglyza Side Effects (in more detail)
  • Onglyza Use in Pregnancy & Breastfeeding
  • Drug Images
  • Onglyza Drug Interactions
  • Onglyza Support Group
  • 7 Reviews for Onglyza - Add your own review/rating


  • Onglyza Prescribing Information (FDA)

  • Onglyza Consumer Overview

  • Onglyza Advanced Consumer (Micromedex) - Includes Dosage Information

  • Onglyza MedFacts Consumer Leaflet (Wolters Kluwer)

  • Saxagliptin Professional Patient Advice (Wolters Kluwer)



Compare Onglyza with other medications


  • Diabetes, Type 2


Where can I get more information?


  • Your pharmacist can provide more information about saxagliptin.

See also: Onglyza side effects (in more detail)


Thursday 4 June 2009

Progesterone Injection




Ingredient matches for Progesterone Injection



Progesterone

Progesterone is reported as an ingredient of Progesterone Injection in the following countries:


  • United States

International Drug Name Search

Wednesday 27 May 2009

Methylphenobarbital




Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

N03AA01

CAS registry number (Chemical Abstracts Service)

0000115-38-8

Chemical Formula

C13-H14-N2-O3

Molecular Weight

246

Therapeutic Category

Antiepileptic agent

Chemical Names

N-Methyl-5-ethyl-5-phenylbarbituric acid (WHO)

2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-1-methyl-5-phenyl- (USAN)

Foreign Names

  • Methylphenobarbitalum (Latin)
  • Methylphenobarbital (German)
  • Méthylphénobarbital (French)
  • Metilfenobarbital (Spanish)

Generic Names

  • Mephobarbital (OS: JAN)
  • Methylphenobarbital (OS: BAN)
  • Méthylphénobarbital (OS: DCF)
  • Metilfenobarbital (OS: DCIT)
  • Enphenemal (IS)
  • Methylphenobarbitone (IS)
  • Mephobarbital (PH: USP 32)
  • Methylphenobarbital (PH: BP 2010, Ph. Eur. 6)
  • Méthylphénobarbital (PH: Ph. Eur. 6)
  • Methylphenobarbitalum (PH: Ph. Eur. 6)

Brand Names

  • Dintoinale (Methylphenobarbital and Phenytoin)
    Pharmarecord, Italy


  • Mebaral
    Lundbeck, United States


  • Methylphenobarbital
    Rekah, Israel


  • Metinal (Methylphenobarbital and Phenytoin)
    Bayer, Italy


  • Phemiton
    Pliva, Bosnia & Herzegowina; Pliva, Croatia (Hrvatska); Pliva, Slovenia

International Drug Name Search

Glossary

BANBritish Approved Name
DCFDénomination Commune Française
DCITDenominazione Comune Italiana
ISInofficial Synonym
JANJapanese Accepted Name
OSOfficial Synonym
PHPharmacopoeia Name
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
USANUnited States Adopted Name
WHOWorld Health Organization

Click for further information on drug naming conventions and International Nonproprietary Names.

Sunday 24 May 2009

Derma-Pax Lotion


Pronunciation: DYE-fen-HYE-dra-meen
Generic Name: Diphenhydramine
Brand Name: Derma-Pax


Derma-Pax Lotion is used for:

Temporarily relieving pain and itching associated with insect bites, minor burns, sunburn, minor skin irritations, minor cuts, scrapes, and rashes due to poison ivy, poison oak, and poison sumac.


Derma-Pax Lotion is an antihistamine. It works by blocking the action of histamine, which reduces the symptoms of an allergic reaction.


Do NOT use Derma-Pax Lotion if:


  • you are allergic to any ingredient in Derma-Pax Lotion

  • you use any other medicine that contains diphenhydramine, unless your doctor tells you to

Contact your doctor or health care provider right away if any of these apply to you.



Before using Derma-Pax Lotion:


Some medical conditions may interact with Derma-Pax Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have the blood disease porphyria

Some MEDICINES MAY INTERACT with Derma-Pax Lotion. Because little, if any, of Derma-Pax Lotion is absorbed into the blood, the risk of it interacting with another medicine is low.


Ask your health care provider if Derma-Pax Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Derma-Pax Lotion:


Use Derma-Pax Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Wash and completely dry the affected area. Gently rub the medicine in until it is evenly distributed. Apply to the affected area not more than 3 to 4 times a day.

  • Wash your hands immediately after using Derma-Pax Lotion.

  • If you miss a dose of Derma-Pax Lotion and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Ask your health care provider any questions you may have about how to use Derma-Pax Lotion.



Important safety information:


  • Derma-Pax Lotion may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.

  • Derma-Pax Lotion is for external use only. Do not get it in your eyes, nose, or mouth. If you get it in your eyes, rinse at once with cool water.

  • If your symptoms do not get better within 7 days or if they get worse, stop using Derma-Pax Lotion and check with your doctor.

  • Do not use Derma-Pax Lotion on chicken pox, measles, or blisters over large areas of your skin unless advised to do so by your doctor.

  • Derma-Pax Lotion contains diphenhydramine. Before you start any new medicine, including one used on the skin, check the label to see if it has diphenhydramine in it too. If it does or if you are not sure, check with your doctor or pharmacist.

  • Derma-Pax Lotion should not be used in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Derma-Pax Lotion while you are pregnant. Derma-Pax Lotion is found in breast milk. If you are or will be breast-feeding while you use Derma-Pax Lotion, check with your doctor. Discuss any possible risks to your baby.


Possible side effects of Derma-Pax Lotion:


All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Skin irritation.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Derma-Pax side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Derma-Pax Lotion may be harmful if swallowed. Symptoms after swallowing Derma-Pax Lotion may include confusion, hallucinations, or loss of consciousness.


Proper storage of Derma-Pax Lotion:

Store Derma-Pax Lotion at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Keep Derma-Pax Lotion out of the reach of children and away from pets.


General information:


  • If you have any questions about Derma-Pax Lotion, please talk with your doctor, pharmacist, or other health care provider.

  • Derma-Pax Lotion is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Derma-Pax Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Derma-Pax resources


  • Derma-Pax Side Effects (in more detail)
  • Derma-Pax Use in Pregnancy & Breastfeeding
  • Derma-Pax Drug Interactions
  • Derma-Pax Support Group
  • 0 Reviews for Derma-Pax - Add your own review/rating


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