Search PLR Article Directory Pakistan: Thyrolar

Generic Name: liotrix (Oral route)

lee-voe-thye-ROX-een SOE-dee-um, lye-oh-THYE-roe-neen SOE-dee-um

Commonly used brand name(s)

In the U.S.

Euthroid

Thyrolar

Available Dosage Forms:

Tablet

Therapeutic Class: Thyroid Supplement

Uses For Thyrolar

Liotrix is used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. It is also used to help decrease the size of enlarged thyroid glands (known as goiter) and to treat thyroid cancer .

Liotrix is also used in some medical tests to help diagnose problems with the thyroid gland .

This medicine is available only with your doctor's prescription .

Before Using Thyrolar

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatrics-specific problems that would limit the usefulness of liotrix in children .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of liotrix in the elderly. However, elderly patients are more likely to have age-related heart and blood vessel problems, which may require caution in patients receiving liotrix .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	A	Adequate studies in pregnant women have not shown an increased risk of fetal abnormalities.

Breast Feeding

Levothyroxine

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Liothyronine

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acenocoumarol

Aluminum Carbonate, Basic

Aluminum Hydroxide

Aluminum Phosphate

Anisindione

Calcium Acetate

Calcium Carbonate

Calcium Citrate

Cholestyramine

Chromium

Colesevelam

Conjugated Estrogens

Dicumarol

Dihydroxyaluminum Aminoacetate

Dihydroxyaluminum Sodium Carbonate

Eltrombopag

Esterified Estrogens

Estradiol

Estriol

Estrone

Estropipate

Imatinib

Iron

Kelp

Lanthanum Carbonate

Lopinavir

Magaldrate

Magnesium Carbonate

Magnesium Hydroxide

Magnesium Oxide

Magnesium Trisilicate

Phenindione

Phenprocoumon

Phenytoin

Rifampin

Rifapentine

Ritonavir

Sevelamer

Simvastatin

Sodium Polystyrene Sulfonate

Soybean

Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Enteral Nutrition

Proper Use of liotrix

This section provides information on the proper use of a number of products that contain liotrix. It may not be specific to Thyrolar. Please read with care.

This medicine usually needs to be taken for the rest of your life. Do not stop taking this medicine or change your doses without first checking with your doctor. It may take several weeks before you start to notice an improvement in your symptoms .

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablet):
- For the treatment of hypothyroidism:
  - Adults—At first, one tablet of liotrix (Thyrolar-1/2) containing 6.25 microgram (mcg) of liothyronine and 25 mcg of levothyroxine once a day. Your doctor may increase your dose by one tablet of liotrix (Thyrolar-1/4) containing 3.1 mcg of liothyronine and 12.5 mcg of levothyroxine every 2 to 3 weeks. However, the dose is usually not more than one tablet of liotrix (Thyrolar-3) containing 37.5 mcg of liothyronine and 150 mcg of levothyroxine once a day.
  - Children—Follow dosing for the treatment of congenital hypothyroidism .
- For the treatment of congenital hypothyroidism:
  - Children 0 to 6 months of age—At first, 3.1 mcg of liothyronine and 12.5 mcg of levothyroxine once a day. Doses may be increased as needed. However, the dose is usually not more than 6.25 mcg of liothyronine and 25 mcg of levothyroxine once a day.
  - Children 6 to 12 months of age—At first, 6.25 mcg of liothyronine and 25 mcg of levothyroxine once a day. Doses may be increased as needed. However, the dose is usually not more than 9.35 mcg of liothyronine and 37.5 mcg of levothyroxine once a day.
  - Children 1 to 5 years of age—At first, 9.35 mcg of liothyronine and 37.5 mcg of levothyroxine once a day. Doses may be increased as needed. However, the dose is usually not more than 12.5 mcg of liothyronine and 50 mcg of levothyroxine once a day.
  - Children 6 to 12 years of age—At first, 12.5 mcg of liothyronine and 50 mcg of levothyroxine once a day. Doses may be increased as needed. However, the dose is usually not more than 18.75 mcg of liothyronine and 75 mcg of levothyroxine once a day.
  - Children over 12 years of age—The usual dose is 18.75 mcg of liothyronine and 75 mcg of levothyroxine once a day. Doses may be increased as needed .

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store in the refrigerator. Do not freeze.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Thyrolar

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests will be needed to check for unwanted effects .

Liotrix should not be used for the treatment of obesity or for the purpose of losing weight. This medicine is ineffective for weight reduction and when taken in larger amount, it may cause more serious medical conditions .

Hypothyroidism can sometimes cause infertility in men and women. Liotrix should not be used for the treatment of infertility unless it is caused by hypothyroidism .

Call your doctor right away if you start to have chest pain, fast or irregular heartbeat, excessive sweating, heat intolerance, nervousness, or any other unusual medical condition .

For patients with diabetes, it is very important that you keep track of your blood or urine sugar levels as instructed by your doctor. Check with your doctor immediately if you notice any changes in your sugar levels .

A temporary loss of hair may occur during the first few months of liotrix therapy. Ask your doctor about this if you have any concerns .

Thyrolar Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not determined

Chest pain

constipation

depressed mood

difficulty in moving

discouragement

dryness of the eye

dry skin and hair

fast, irregular, pounding, or racing heartbeat or pulse

fear, nervousness

feeling cold

feeling sad or empty

fever

headache

hives or welts

hoarseness or husky voice

increased sweating

increased weight

increase in blood pressure

irritability

irritation

itching skin

joint pain, stiffness or swelling

lack of appetite

lack or loss of strength

loss of interest or pleasure

muscle aching or cramping

muscle pain or stiffness

nausea

redness of skin

shakiness in legs, arms, hands, feet

shortness of breath

skin rash

sleeplessness

slowed heartbeat

sluggishness

swelling of eyelids, face, lips, hands, or feet

swollen joints

tightness in chest

tiredness

trembling or shaking of hands or feet

trouble concentrating

troubled breathing or swallowing

trouble sleeping

unable to sleep

unusual tiredness or weakness

weight gain

wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not determined

Hair loss, thinning of hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Thyrolar side effects (in more detail)

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More Thyrolar resources

Thyrolar Side Effects (in more detail)
Thyrolar Dosage
Thyrolar Use in Pregnancy & Breastfeeding
Drug Images
Thyrolar Drug Interactions
Thyrolar Support Group
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Liotrix Professional Patient Advice (Wolters Kluwer)

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Liotrix Monograph (AHFS DI)

Liotrix MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Thyrolar with other medications

Underactive Thyroid

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Monday 5 March 2012

Thyrolar