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Generic Name: flecainide (Oral route)

FLEK-a-nide

Oral route(Tablet)

Excessive mortality or nonfatal cardiac arrest rate was seen in patients with asymptomatic nonlife-threatening ventricular arrhythmias and myocardial infarction more than six days but less than two years previously who received flecainide compared with patients assigned to a carefully matched placebo in the Cardiac Arrhythmia Suppression Trial (CAST). It is prudent to consider the risks of Class IC agents (including flecainide), coupled with the lack of any evidence of improved survival, generally unacceptable in a patient without life-threatening ventricular arrhythmias, even if the patient is experiencing unpleasant, but not life-threatening, symptoms or signs. Flecainide is not recommended for use in patients with chronic atrial fibrillation. Case reports of ventricular proarrhythmic effects in patients treated with flecainide for atrial fibrillation/flutter have included increased PVCs, VT, ventricular fibrillation (VF), and death .

Commonly used brand name(s)

In the U.S.

Tambocor

Available Dosage Forms:

Capsule, Extended Release

Tablet

Therapeutic Class: Antiarrhythmic, Group IC

Chemical Class: Amino Amide

Uses For Tambocor

Flecainide is used to prevent or treat irregular heartbeats (arrhythmias) such as paroxysmal supraventricular tachycardia (PSVT) and paroxysmal atrial fibrillation/flutter (PAF). Flecainide is also used to prevent life-threatening sustained ventricular tachycardia (sustained VT).

Flecainide belongs to the group of medicines known as antiarrhythmics. It works directly on the heart tissue and will slow the nerve impulses in the heart. This helps keep the heart rhythm normal.

There is a chance that flecainide may cause new or make worse existing heart rhythm problems when it is used. Since it has been shown to cause severe problems in some patients, it is only used to treat serious heart rhythm problems. Discuss this possible effect with your doctor.

This medicine is available only with your doctor's prescription.

Before Using Tambocor

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of flecainide in the pediatric population. Safety and efficacy have not been established, but your doctor may choose to use this medication in children with serious heart rhythm problems

Geriatric

No information is available on the relationship of age to the effects of flecainide in elderly patients. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving flecainide.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Bepridil

Cisapride

Dronedarone

Levomethadyl

Mesoridazine

Pimozide

Ritonavir

Saquinavir

Sparfloxacin

Terfenadine

Thioridazine

Tipranavir

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acecainide

Ajmaline

Alfuzosin

Amiodarone

Amisulpride

Amitriptyline

Amoxapine

Apomorphine

Aprindine

Arbutamine

Arsenic Trioxide

Asenapine

Astemizole

Azimilide

Azithromycin

Bendroflumethiazide

Boceprevir

Bretylium

Chloral Hydrate

Chloroquine

Chlorothiazide

Chlorpromazine

Chlorthalidone

Ciprofloxacin

Citalopram

Clarithromycin

Clomipramine

Crizotinib

Darifenacin

Darunavir

Dasatinib

Delavirdine

Desipramine

Dibenzepin

Disopyramide

Dofetilide

Dolasetron

Droperidol

Duloxetine

Enflurane

Erythromycin

Etravirine

Flecainide

Fluconazole

Fluoxetine

Foscarnet

Gatifloxacin

Gemifloxacin

Granisetron

Halofantrine

Haloperidol

Halothane

Hydrochlorothiazide

Hydroflumethiazide

Hydroquinidine

Ibutilide

Iloperidone

Imipramine

Isoflurane

Isradipine

Lapatinib

Levofloxacin

Lidocaine

Lidoflazine

Lorcainide

Lumefantrine

Mefloquine

Methadone

Metolazone

Moxifloxacin

Nilotinib

Norfloxacin

Nortriptyline

Octreotide

Ofloxacin

Ondansetron

Paliperidone

Pazopanib

Pentamidine

Perflutren Lipid Microsphere

Pirmenol

Polythiazide

Posaconazole

Prajmaline

Prilocaine

Probucol

Procainamide

Prochlorperazine

Promethazine

Propafenone

Protriptyline

Quetiapine

Quinidine

Ranolazine

Risperidone

Salmeterol

Sematilide

Sertindole

Sertraline

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Solifenacin

Sorafenib

Sotalol

Spiramycin

Sulfamethoxazole

Sultopride

Sunitinib

Tedisamil

Telaprevir

Telavancin

Telithromycin

Tetrabenazine

Toremifene

Trazodone

Trichlormethiazide

Trifluoperazine

Trimethoprim

Trimipramine

Vandetanib

Vardenafil

Vasopressin

Vemurafenib

Voriconazole

Zolmitriptan

Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amiodarone

Bupropion

Cimetidine

Clozapine

Digoxin

Paroxetine

Propranolol

Protriptyline

Verapamil

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of Tambocor

In some cases, you will receive your first dose of this medicine in a hospital. Your doctor will watch you closely after you take this medicine to make sure you do not have any serious side effects.

Take this medicine exactly as directed by your doctor even though you may feel well. Do not take more medicine than your doctor ordered.

This medicine may be taken with or without food.

This medicine works best when there is a constant amount in the blood. To help keep this amount constant, do not miss any doses. Also, it is best to take the doses 12 hours apart, in the morning and at night, unless otherwise directed by your doctor. If you need help in planning the best times to take your medicine, check with your doctor.

In infants (less than 2 years of age) who drink a lot of milk, your doctor may adjust the dose of this medicine when it is time to reduce the amount of milk your infant is receiving, or if they develop gastroenteritis. Talk with your doctor if you have questions about this.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):
- For paroxysmal supraventricular tachycardia (PSVT) and paroxysmal atrial fibrillation/flutter (PAF):
  - Adults—At first, 50 milligrams (mg) every 12 hours. Your doctor may increase your dose as needed.
  - Children—Use and dose must be determined by your doctor. Dose is based on body size and must be determined by your child's doctor. The starting dose is 100 milligrams (mg) per square meter (m[2]) per day for infants 6 months and older and 50 mg/m(2) per day in infants younger than 6 months. Doses are divided into two or three equal doses per day.
- For sustained ventricular tachycardia (sustained VT):
  - Adults—At first, 100 milligrams (mg) every 12 hours. Your doctor may increase your dose as needed. However, the dose is usually not more than 400 mg per day.
  - Children—Use and dose must be determined by your doctor. Dose is based on body size and must be determined by your child's doctor. The starting dose is 100 milligrams (mg) per square meter (m[2]) per day for infants 6 months and older and 50 mg/m(2) per day in infants younger than 6 months. Doses are divided into two or three equal doses per day.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Tambocor

It is important that your doctor check your progress at regular visits to make sure the medicine is working properly. This will allow for changes to be made in the amount of medicine you are taking, if necessary.

Check with your doctor right away if you develop any of the following: chest pain; shortness of breath; swelling of your hands, ankles, or feet; or weight gain. These may be symptoms of heart failure.

This medicine can cause changes in your heart rhythm, such as conditions called PR, QRS, or QT prolongation. It may cause fainting or serious side effects in some patients. Contact your doctor right away if your symptoms do not improve or if they become worse.

Your doctor may want you to carry a medical identification card or bracelet stating that you are using this medicine.

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine.

Flecainide may cause some people to become dizzy, lightheaded, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.

If you have been using this medicine regularly for several weeks, do not suddenly stop using it. Check with your doctor for the best way to gradually reduce the amount you are taking before stopping completely.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Tambocor Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Difficult or labored breathing

dizziness, fainting, or lightheadedness

fast, irregular, pounding, or racing heartbeat or pulse

shortness of breath

tightness in the chest

wheezing

Less common

Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain

fainting

feeling of warmth

fever

increased sweating

partial or slight paralysis

redness of the face, neck, arms, and occasionally, upper chest

shakiness and unsteady walk

shakiness in the legs, arms, hands, or feet

swelling of the feet or lower legs

trembling or shaking of the hands or feet

unsteadiness, trembling, or other problems with muscle control or coordination

Rare

Arm, back, or jaw pain

black, tarry stools

bleeding gums

blood in the urine or stools

blurred vision

chest discomfort

chest tightness or heaviness

chills

confusion

convulsions

cough

decrease in the frequency of urination

decrease in urine volume

difficulty in passing urine (dribbling)

difficulty with breathing

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

frequent urination

general feeling of discomfort or illness

headache

increased volume of pale, dilute urine

nausea

nervousness

noisy breathing

painful or difficult urination

pinpoint red spots on the skin

pounding in the ears

sensation of pins and needles

slow or fast heartbeat

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stabbing pain

sweating

swollen glands

thickening of bronchial secretions

troubled breathing

unusual bleeding or bruising

unusual tiredness or weakness

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Blurred vision or seeing spots

Less common

Abdominal or stomach pain

acid or sour stomach

anxiety or mental depression

belching

constipation

continuing ringing or buzzing or other unexplained noise in the ears

depression

diarrhea

feeling of constant movement of self or surroundings

general feeling of discomfort or illness

hearing loss

heartburn

indigestion

lack or loss of strength

loss of appetite

sensation of spinning

sleepiness or unusual drowsiness

sleeplessness

skin rash

stomach discomfort, upset, or pain

trouble with sleeping

unable to sleep

weight loss

Rare

Bloated

change in color vision

change in taste

cracks in the skin

decreased awareness or responsiveness

decreased interest in sexual intercourse

difficulty seeing at night

difficulty with moving

dry mouth

excess air or gas in the stomach or intestines

eye pain or irritation

false or unusual sense of well-being

feeling of unreality

full feeling

hair loss or thinning of the hair

hives or welts

inability to have or keep an erection

increased sensitivity of the eyes to sunlight

itching skin

joint pain

lack of feeling or emotion

loss in sexual ability, desire, drive, or performance

loss of heat from the body

loss of memory

muscle aching or cramping

muscle pain or stiffness

passing gas

problems with memory

red, swollen skin

scaly skin

sense of detachment from self or body

severe sleepiness

swollen joints

swollen lips, mouth, or tongue

uncaring uncontrolled eye movements

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Tambocor side effects (in more detail)

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More Tambocor resources

Tambocor Side Effects (in more detail)
Tambocor Use in Pregnancy & Breastfeeding
Drug Images
Tambocor Drug Interactions
Tambocor Support Group
7 Reviews for Tambocor - Add your own review/rating

Tambocor Prescribing Information (FDA)

Tambocor MedFacts Consumer Leaflet (Wolters Kluwer)

Tambocor Concise Consumer Information (Cerner Multum)

Tambocor Monograph (AHFS DI)

Flecainide Prescribing Information (FDA)

Compare Tambocor with other medications

Atrial Fibrillation
Atrial Flutter
Paroxysmal Supraventricular Tachycardia
Supraventricular Tachycardia
Ventricular Tachycardia
Wolff-Parkinson-White Syndrome

Search PLR Article Directory Pakistan

Saturday 21 April 2012

Tambocor